Since Protiviti published Issue 8 of Volume III of The Bulletin, "Setting the 2009 Audit Committee Agenda," the world has continued to change. Without question, we live in a vastly different world than that of a year ago and the environment remains dynamic and challenging. Given where things stand today and looking forward into 2010, this issue of The Bulletin provides observations and ideas for consideration by boards and their audit committees. To provide a context for setting the 2010 audit committee agenda, this issue describes 10 major challenges businesses face.